Received: by alpheratz.cpm.aca.mmu.ac.uk id HAA14064 (8.6.9/5.3[ref pg@gmsl.co.uk] for cpm.aca.mmu.ac.uk from fmb-majordomo@mmu.ac.uk); Tue, 13 Feb 2001 07:32:12 GMT Date: Tue, 13 Feb 2001 12:52:17 +0530 (IST) From: Dr Able Lawrence <able@sgpgi.ac.in> To: memetics@mmu.ac.uk Subject: Re: Human Genome In-Reply-To: <3A88796C.623.E1B82E@localhost> Message-ID: <Pine.LNX.4.10.10102131251580.22689-100000@sushrut.sgpgi.ac.in> Content-Type: TEXT/PLAIN; charset=US-ASCII Sender: fmb-majordomo@mmu.ac.uk Precedence: bulk Reply-To: memetics@mmu.ac.uk
Yeah! just missed a keystroke!!
On Tue, 13 Feb 2001 joedees@bellsouth.net wrote:
> On 13 Feb 2001, at 11:08, Dr Able Lawrence wrote:
>
> That's 30,000.
> >
> > Hi All,
> > Genome report (only 3000 genes) is not really surprising at
> > all if
> > we understand the implications of the recently discovered complexities
> > in gene expression regulation The transcription factors are huge multi
> > subunit complexes with countless interactions amongst them. The
> > permutation and combination possible for interactions amongst
> > transcription factors is realy mind boggling. There is more to
> > genetics than mere genes and DNA sequences.
> > The real implication of the new finding is that one gene- one
> > function hypothesis is dead. Now we know that a single gene can
> > produce myriad proteins like the immunoglobuin or T cell receptor or
> > neural adhesion molecules involved in the complex wiring of the
> > nervous system. On the contrary multiple genes are required for
> > functional units (multi subunit complexes) involved in such vital
> > functions as regulation of gene expression or respiration or protein
> > synthesis.
> > A lot of the complexity in higher organism is probably at the
> > level
> > of gene-gene interactions and the complex cascading and epigenetic
> > effects on gene expression.
> > To emphasize the point further, all our cells have the same DNA
> > sequence (well almost) but are morphologically and functionally
> > diverse.
> > So it is not necessary to have different sets of genes but more
> > fine
> > tuned interactions to create us humans.
> > As I pointed out earlier that smple minor variations in gene
> > expressions can have profound morphological implications. So the gene
> > regulating embryogenesis (Hox genes) are highly conserved vertically
> > in the evolutionary ladder (ladder itself is an anthropocentric view
> > and other organisms can object!)
> > Throughout evolution new functions have rarely ever come about by
> > inventing new genes (it takes too much directed ingenuity for that,
> > may be only Lamarck or biotechnologists a few decades down the line
> > can only do it) but by making new use or modifying old genes. Once
> > useful but rudimentary function is discovered for an old gene,
> > variation and evolution (and duplication if the old gene already has
> > an indispensable function) would be favoured and would arise in due
> > course of time. Duplication of genes in malignant clones in the body
> > is a case in point.
> > It would be ridiculous to say that the multidrug resistance gene in
> > human malignancy had the same function before that begins to get
> > favoured by surviving tumour cells.
> > We must view genes as dynamically interacting
> > information
> > and also should not forget that the genes get their properties through
> > the proteins they encode (with all the complexities of protein
> > chemistry and protein protein interaction)
> >
> > Anthropocentrism is alive only in Christian theology!!
> >
> >
> > ~~~~~~~~~~~~~~~~~~~
> > Dr Able Lawrence MD
> > Senior Resident
> > Clinical Immunology
> > SGPGIMS, Lucknow
> > able@sgpgi.ac.in
> > Ph +91 98390 70247
> > ~~~~~~~~~~~~~~~~~~~
> >
> >
> > ===============================================================
> > This was distributed via the memetics list associated with the
> > Journal of Memetics - Evolutionary Models of Information Transmission
> > For information about the journal and the list (e.g. unsubscribing)
> > see: http://www.cpm.mmu.ac.uk/jom-emit
> >
> >
>
>
>
> ===============================================================
> This was distributed via the memetics list associated with the
> Journal of Memetics - Evolutionary Models of Information Transmission
> For information about the journal and the list (e.g. unsubscribing)
> see: http://www.cpm.mmu.ac.uk/jom-emit
>
~~~~~~~~~~~~~~~~~~~
Dr Able Lawrence MD
Senior Resident
Clinical Immunology
SGPGIMS, Lucknow
able@sgpgi.ac.in
Ph +91 98390 70247
~~~~~~~~~~~~~~~~~~~
===============================================================
This was distributed via the memetics list associated with the
Journal of Memetics - Evolutionary Models of Information Transmission
For information about the journal and the list (e.g. unsubscribing)
see: http://www.cpm.mmu.ac.uk/jom-emit
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