RE: MIT research reports rats dream of mazes

From: Gatherer, D. (Derek) (D.Gatherer@organon.nhe.akzonobel.nl)
Date: Fri Jan 26 2001 - 07:58:52 GMT

  • Next message: Gatherer, D. (Derek): "RE: MIT research reports rats dream of mazes"

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    From: "Gatherer, D. (Derek)" <D.Gatherer@organon.nhe.akzonobel.nl>
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    Subject: RE: MIT research reports rats dream of mazes
    Date: Fri, 26 Jan 2001 08:58:52 +0100
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    Here you go, Lawrence:
    This is apparently in Japanese, so there's no point me ordering it from the
    library, but I think the abstract is fairly clear. So it is possible to
    selectively breed lines of clever and dim rats. But there's no indication
    here of what steps were taken to prevent the rats somehow culturally
    acquiring the maze learning ability. It just isn't an issue that arises, as
    it is simply assumed that rats are a culture-free zone. I'll keep looking.

    Jikken Dobutsu 1984 Oct;33(4):471-9

    [The effects of rat selection and reproduction on learning ability in the
    offspring].

    [Article in Japanese]

    Yamada T, Uchida H, Nishiyama T

    We studied the effect of selective reproduction on rats purchased from a
    breeder, so as to detect learning impairments in their offspring. The parent
    rats selected for mating were categorized as bright or dull in terms of
    learning ability on the basis of a learning test in a water maze or passive
    avoidance response (PAR). Offspring were tested in the same way as the
    selected rats, with their responses being compared for each generation. 1.
    The matings, consisting of bright X bright, bright X dull, dull X bright,
    dull X dull, resulted in a significant increase in the number of dull
    offspring of dull X dull from parents selected by water maze or PAR learning
    test. 2. Bright or dull mothers selected by PAR learning were treated with
    chlorpromazine 6 mg/kg (2 times/day/s.c.) on the 13th day of gestation.
    Afterwards, a slight increase in dull offspring of dull parents was seen. 3.
    These results indicate that in order to evaluate the learning ability of F1
    in a reproductive test, it is first necessary to check the reaction of the
    parents, purchased F0, and to classify them as bright or dull.

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