Date: Fri, 14 May 1999 13:37:49 +0200
From: "Gatherer, D. (Derek)" <D.Gatherer@organon.nhe.akzonobel.nl>
Subject: genetic susceptibility to depression
To: "'memetics@mmu.ac.uk'" <memetics@mmu.ac.uk>
Is this what you're after, Dave? (I couldn't find anything from Texas....)
Am J Psychiatry 1999 Feb;156(2):209-15
Functional MRI study of the cognitive generation of affect.
Teasdale JD, Howard RJ, Cox SG, Ha Y, Brammer MJ, Williams SC, Checkley SA
Institute of Psychiatry, University of London, England.
OBJECTIVE: The authors investigated, by whole brain functional magnetic
resonance imaging (MRI), the neural substrate underlying processing of
emotion-related meanings. METHOD: Six healthy subjects underwent functional
MRI while viewing 1) alternating blocks of pairs of pictures and captions
evoking negative feelings and the same materials irrelevantly paired to
produce less emotion (reference pairs); 2) alternating blocks of
picture-caption pairs evoking positive feelings and the same materials
irrelevantly paired to produce less emotion; and 3) alternating blocks of
picture-caption pairs evoking positive feelings and picture-caption pairs
evoking negative feelings.
RESULTS: Compared with the reference picture-caption pairs, negative pairs
activated the right medial and middle frontal gyri, right
anterior cingulate gyrus, and right thalamus. Compared with the reference
picture-caption pairs, positive pairs activated the right and left insula,
right inferior frontal gyrus, left splenium, and left precuneus. Compared
with the negative picture-caption pairs, positive pairs activated the right
and left medial frontal gyri, right anterior cingulate gyrus, right
precentral gyrus, and left caudate. CONCLUSIONS:
Contrasts of both 1) negative and reference picture-caption pairs and 2)
positive and negative picture-caption pairs activated networks involving
similar areas in the medial frontal gyrus (Brodmann's area 9) and right
anterior cingu-late gyrus (areas 24 and 32). The area 9 sites activated are
strikingly similar to sites activated in related positron emission
tomography experiments. Activation of these same sites by a range of evoked
affects, elicited by different methods, is consistent with areas within the
medial prefrontal cortex mediating the processing of affect-related
meanings, a process common to many forms of emotion production.
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